Pressure-induced disorders

Neurosci Biobehav Rev. 1992 Winter;16(4):597-602.

A hypothesis regarding possible interactions between the pressure-induced disorders in dopaminergic and amino-acidergic transmission.

Source

Unité de Neuropsychiatrie, C.H.U. de Sart Tilman, Liège, Belgigue.

Abstract

When human divers or experimental animals are exposed to high pressure they develop the high pressure neurological syndrome (HPNS). The main symptoms include electroencephalographic changes and behavioral disturbances such as tremor, myoclonia, and hyperlocomotor activity. Recently, pressure-induced disorders in dopaminergic and amino-acidergic neurotransmission have been reported. In the present theoretical study, we review in vitro and in vivo neurochemical, electrophysiological, and pharmacobehavioral evidence concerning alterations in dopaminergic, glutamatergic, and GABAergic transmission occurring at high pressure, and their possible relationship to the symptoms of HPNS. Moreover, we also examine data concerning interactions, at normal pressure, between dopaminergic, glutamatergic, and GABAergic transmission that we suggest they could apply equally under high pressure between the pressure-induced disorders in dopaminergic and amino-acidergic transmission.

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Pressure-induced disorders

Biol Psychiatry. 1993 Nov 1;34(9):622-9.

Pressure-induced disorders in neurotransmission and spontaneous behavior in rats: an animal model of psychosis.

Source

Unité de Neuropsychiatrie, C.H.U. Sart Tilman, Liège, Belgium.

Abstract

Disorders in neurotransmission and spontaneous behavior in rats exposed to a high pressure helium-oxygen mixture that shows interesting parallels with the dopaminergic hypothesis of schizophrenia at both the biochemical and the therapeutic responding levels are reviewed. Furthermore, as human subjects exposed to a very high pressure have shown psychotic episodes, we conclude that the pressure-induced disorders in neurotransmission and spontaneous behavior in rats could constitute a valid animal model of schizophreniform psychosis and a useful tool for both the investigation of the biological mechanisms underlying schizophrenia and the development of new antipsychotic drugs.

PMID:
7904834
[PubMed – indexed for MEDLINE]

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