Creutzfeld-Jacob like syndrome due to lithium toxicity.

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J Neurol Neurosurg Psychiatry. 1989 February; 52(2): 291.
PMCID: PMC1032531

Creutzfeld-Jacob like syndrome due to lithium toxicity.


Drug-induced Creutzfeldt-Jakob like syndrome.

J Psychiatry Neurosci. 1992 Sep;17(3):103-5.


Department of Neurology, Hahnemann University, Philadelphia, Pennsylvania.


A patient with progressive neurological deterioration characterized by cognitive impairment, myoclonus, Parkinson’s syndrome, an abnormal electroencephalogram and fasciculations was considered for brain biopsy for suspected Creutzfeldt-Jakob disease. Complete clinical recovery followed discontinuation of lithium and nortriptyline. Awareness of this unusual drug-induced Creutzfeldt-Jakob like syndrome can avoid costly, invasive and unnecessary investigative procedures.

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