Recurrent UTIs linked to acute psychosis in schizophrenia

By Rita Buckley

Recurrent urinary tract infections (UTIs) may be common in schizophrenic patients with acute psychosis, according to a small study.

Schizophrenia is known to be associated with an increased risk of infections, and studies have found a link between acute psychotic relapse and an elevated prevalence of UTI.

It’s not clear whether acute psychosis in schizophrenia is linked to recurrent UTIs, however, Dr. Brian J. Miller and colleagues from Georgia Regents University in Augusta write in a letter to the editor in Schizophrenia Research, online March 10.

The team reviewed the medical records of 152 patients with at least two hospitalizations between 2008-2013 for schizophrenia or schizoaffective disorder.

Twenty-five patients, or 16%, had two or more UTIs, defined as positive leukocyte esterase and/or nitrates and at least 5-10 leukocytes/high-powered field on urinalysis.

These patients had a UTI on 59% (64/109) of their admissions. They also had significantly higher absolute monocyte and eosinophil counts, and lower differential lymphocyte count during admissions with UTI versus without it.

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