Case Report

Caffeine-Induced Psychosis

Dawson W. Hedges c1, Fu Lye Woon and Scott P. Hoopes


As a competitive adenosine antagonist, caffeine affects dopamine transmission and has been reported to worsen psychosis in people with schizophrenia and to cause psychosis in otherwise healthy people. We report of case of apparent chronic caffeine-induced psychosis characterized by delusions and paranoia in a 47-year-old man with high caffeine intake. The psychosis resolved within 7 weeks after lowering caffeine intake without use of antipsychotic medication. Clinicians might consider the possibility of caffeinism when evaluating chronic psychosis.


  1. Thank you for this article. I was initially diagnosed with drug induced psychosis in 2011. I was treated with antipsychotic meds. Since 2014 I haven’t taken any medication. Daily caffeine use does seem to trigger symptoms for me. This has been the only exposure, as I no longer smoke cigarettes or consume alcohol. When I cut back on coffee and drink more water, the symptoms seem to subside.

    1. Hi Greg,
      I experienced psychosis from toxic encephalopathy, long-term chemical exposure in the workplace and also have the same problem with caffeine.

      Very sad that mental health professionals refuse to consider the underlying causes of psychosis and instead believe in their treatment of choice.

      Thank you for your comment.

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