Cimetidine-induced psychosis in a 14-year-old girl.


A 14-year-old girl presented with hallucinations and bizarre behaviour 3 days following the institution of cimetidine therapy for acute gastritis. She had no history of drug abuse or psychiatric disorders, and physical examination and laboratory investigations yielded no abnormalities. Within 24 hours after cimetidine therapy was discontinued her behaviour returned to normal and the hallucinations stopped.

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(cimetidine) Tablets
(cimetidine hydrochloride) Liquid
(cimetidine hydrochloride) Injection

Tagamet (cimetidine) is a histamine H2-receptor antagonist. Chemically it is N?-cyano-N-methyl N’-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]-ethyl]-guanidine.

The empirical formula for cimetidine is C10H16N6S and for cimetidine hydrochloride, C10H16N6SHCl; these represent molecular weights of 252.34 and 288.80, respectively.

Cimetidine contains an imidazole ring, and is chemically related to histamine.

(The liquid and injection dosage forms contain cimetidine as the hydrochloride.)

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Published on Oct 12, 2012 by Simon Gargette
Tagamet ‘Future’ SFX Commercial Dir: Simon Gargette

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