Pressure-induced disorders in neurotransmission and spontaneous behavior in rats: an animal model of psychosis.
Unité de Neuropsychiatrie, C.H.U. Sart Tilman, Liège, Belgium.
Disorders in neurotransmission and spontaneous behavior in rats exposed to a high pressure helium-oxygen mixture that shows interesting parallels with the dopaminergic hypothesis of schizophrenia at both the biochemical and the therapeutic responding levels are reviewed. Furthermore, as human subjects exposed to a very high pressure have shown psychotic episodes, we conclude that the pressure-induced disorders in neurotransmission and spontaneous behavior in rats could constitute a valid animal model of schizophreniform psychosis and a useful tool for both the investigation of the biological mechanisms underlying schizophrenia and the development of new antipsychotic drugs.
- [PubMed – indexed for MEDLINE]