Service de Neurologie et Pathologie du Mouvement, EA 2683, Hôpital Roger Salengro, rue du Professeur Emile Laine, CHRU, 59037 Lille Cedex.
Creutzfeldt-Jakob disease (CJD) has a poor prognosis. Certain clinical presentations can be suggestive yet mimic a curable disease.
In the present study, we report the case of a 67-year-old man with a one-month history of progressive dementia, with myoclonic jerks and cerebellar syndrome suggesting a diagnosis of Creutzfeldt-Jakob encephalopathy. He had been treated for 9 years with lithium for a bipolar disorder. The results of the different investigations and the favorable course after discontinuation of lithium were in favor of the diagnosis of drug-induced Creutzfeldt-Jakob syndrome.
This case illustrates the importance for researching a curable etiology in presence of clinical features suggesting a CJD.