Psychoses as the presenting manifestation of Creutzfeldt-Jakob disease in an elderly male

Gen Hosp Psychiatry. 2011 May-Jun;33(3):302.e7-9. Epub  2011 Mar 24.

Li X, Lapid MI, Burton MC, Josephs KA.


Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.


The differential diagnosis of acute psychosis includes delirium, dementia and primary psychiatric disorders. A comprehensive medical evaluation is crucial to make the proper diagnosis. We report the case of a healthy elderly man who presents with acute psychosis. We describe our diagnostic evaluation based on the patient’s history and physical examination, which identified Creutzfeldt-Jakob disease. Avoiding diagnostic error in patients who face such a rapidly progressive and catastrophic illness is paramount.

Uploaded by on Jul  3, 2008

WTHR from Indianpolis aired this documentary in the Fall of 2006.  My brother was Zane Mingus.

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