Hashimoto’s encephalopathy masquerading as acute psychosis.

J Clin Neurosci. 2008 Nov;15(11):1301-4. Epub  2008 Mar 7.


Department of Neurology, Level 2, Flinders Medical Centre, Bedford Park, Adelaide 5042, South Australia, Australia.


Hashimoto’s encephalopathy (HE) is a relapsing, but exquisitely corticosteroid-responsive encephalopathy associated with autoimmune thyroiditis. Although a rare disease, with just over 100 cases reported, it may be under-recognised. Its presentation can be protean with prominent neuropsychiatric features, stroke-like episodes, seizures and myoclonic jerks. Prompt corticosteroid treatment usually leads to rapid recovery. Here we report a patient with HE, initially presenting with florid neuropsychiatric symptoms. Recent developments in the understanding of this condition are discussed.

[PubMed – indexed for MEDLINE]

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