Methylphenidate-induced psychosis in adult attention-deficit/hyperactivity disorder: report of 3 new cases and review of the literature.

Clin Neuropharmacol. 2010 Jul;33(4):204-6.



Outpatient Clinic for Adult ADHD, Department of Psychiatry and Psychotherapy, University of Duisburg-Essen, LVR Clinic Essen; and daggerDepartment of Neurology, Alfried Krupp Hospital Essen, Essen, Germany.



We present 3 new cases of psychotic symptoms in patients with adult attention-deficit/hyperactivity disorder while regularly treated with a stimulant therapy with methylphenidate.


Existing literature about this theme is reviewed, and potential mechanisms are discussed.


Medication with methylphenidate should be avoided in patients with vulnerability to schizophrenia and in drug addiction, but reported cases without these risk factors demonstrate that a careful and regular psychiatric monitoring is essential in all patients treated with methylphenidate.

[PubMed – indexed for MEDLINE]

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